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Hyperglycemia potentiates the slowing of gastric emptying induced by exogenous GLP-1
- Source :
- Diabetes care. 38(6)
- Publication Year :
- 2014
-
Abstract
- OBJECTIVE Acute hyperglycemia markedly slows gastric emptying. Exogenous GLP-1 also slows gastric emptying, leading to diminished glycemic excursions. The primary objective was to determine whether hyperglycemia potentiates the slowing of gastric emptying induced by GLP-1 administration. RESEARCH DESIGN AND METHODS Ten healthy participants were studied on 4 separate days. Blood glucose was clamped at hyperglycemia using an intravenous infusion of 25% dextrose (∼12 mmol/L; hyper) on 2 days, or maintained at euglycemia (∼6 mmol/L; eu) on 2 days, between t = −15 and 240 min. During hyperglycemic and euglycemic days, participants received intravenous GLP-1 (1.2 pmol/kg/min) and placebo in a randomized double-blind fashion. At t = 0 min, subjects ingested 100 g beef mince labeled with 20 MBq technetium-99m–sulfur colloid and 3 g 3-O-methyl-glucose (3-OMG), a marker of glucose absorption. Gastric emptying was measured scintigraphically from t = 0 to 240 min and serum 3-OMG taken at regular intervals from t = 15 to 240 min. The areas under the curve for gastric emptying and 3-OMG were analyzed using one-way repeated-measures ANOVA with Bonferroni-Holm adjusted post hoc tests. RESULTS Hyperglycemia slowed gastric emptying (eu/placebo vs. hyper/placebo; P < 0.001) as did GLP-1 (eu/placebo vs. eu/GLP-1; P < 0.001). There was an additive effect of GLP-1 and hyperglycemia, such that gastric emptying was markedly slower compared with GLP-1 administration during euglycemia (eu/GLP-1 vs. hyper/GLP-1; P < 0.01). CONCLUSIONS Acute administration of exogenous GLP-1 profoundly slows gastric emptying during hyperglycemia in excess of the slowing induced by GLP-1 during euglycemia. Studies are required to determine the effects of hyperglycemia on gastric emptying with the subcutaneously administered commercially available GLP-1 agonists in patients with type 2 diabetes.
- Subjects :
- Blood Glucose
Male
endocrine system
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Type 2 diabetes
Placebo
gastric emptying
Double-Blind Method
Gastrointestinal Agents
Glucagon-Like Peptide 1
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
blood glucose
Humans
Hypoglycemic Agents
Insulin
Infusions, Intravenous
Glycemic
Aged
Advanced and Specialized Nursing
Gastrointestinal agent
Analysis of Variance
Gastric emptying
business.industry
digestive, oral, and skin physiology
Middle Aged
medicine.disease
Glucagon-like peptide-1
Healthy Volunteers
Endocrinology
Glucose
Diabetes Mellitus, Type 2
Gastric Emptying
Hyperglycemia
Female
hyperglycemia
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 19355548
- Volume :
- 38
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Diabetes care
- Accession number :
- edsair.doi.dedup.....7e5ebfd68c8e77c4ef77c7084af7f8c2