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HLA Expression at the Maternal-Fetal Interface
- Source :
- Developmental Immunology, Clinical and Developmental Immunology, Vol 6, Iss 3-4, Pp 197-204 (1998)
- Publication Year :
- 1998
- Publisher :
- Hindawi Publishing Corporation, 1998.
-
Abstract
- Pregancy in the human presents an “immunological paradox,” because of the unexpected willingness of mothers to accept genetically disparate tissues. The fact that the fetus can develop unharmed for nine months shows that protective mechanisms must exist to permit its survival. The conditions that permit the genetically dissimilar human fetus to evade rejection by its mother's immune system have been the subject of intense interest for several decades. As the placental cells, which are in contact with maternal blood or tissue, are devoid of HLA class II antigens, interest has focused on the expression of HLA class molecules. Recent developments in the constitutive, transcriptional, and translational expression of HLA class I molecules on anatomically and morphologically different subpopulations of trophoblast cells will form the basis of this short review.
- Subjects :
- lcsh:Immunologic diseases. Allergy
placenta
HLA class l
Genes, MHC Class I
Human leukocyte antigen
Biology
immunology
Immune system
Antigen
Pregnancy
Placenta
MHC class I
medicine
Humans
Gene
Maternal-Fetal Exchange
Fetus
Histocompatibility Antigens Class I
Trophoblast
trophoblast
Trophoblasts
medicine.anatomical_structure
Immunology
biology.protein
Female
MHC
lcsh:RC581-607
Developmental Biology
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 10446672
- Volume :
- 6
- Issue :
- 3-4
- Database :
- OpenAIRE
- Journal :
- Developmental Immunology
- Accession number :
- edsair.doi.dedup.....7e554013dd26c21d81da907527281288