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Early Experience with Magnesium Administration in Irukandji Syndrome
- Source :
- Anaesthesia and Intensive Care. 32:666-669
- Publication Year :
- 2004
- Publisher :
- SAGE Publications, 2004.
-
Abstract
- The administration of magnesium sulphate is a proposed novel therapy for Irukandji syndrome1. In this non-randomized, unblinded case series, data from ten patients who received magnesium salts are reviewed. Magnesium sulphate boluses of 10 to 20 mmol, in the six patients for which there was adequate data, reduced pain scores immediately after administration from 8.7±1.5 to 2.8±2.8 (Wilcoxon rank-sum test, P=0.03). In ten patients blood pressure decreased with a mean difference of −18 mmHg in mean arterial pressure. Magnesium requirements in individual patients varied markedly. Pain on injection occurred in four patients, three of whom had received peripherally administered magnesium chloride, and one patient reported transient ptosis after administration of magnesium sulphate 166 mmol over 18 hours in the setting of severe Irukandji syndrome. Magnesium sulphate administration appears to attenuate pain and hypertension in Irukandji syndrome and warrants further evaluation in this setting.
- Subjects :
- Male
Mean arterial pressure
Pain
chemistry.chemical_element
Critical Care and Intensive Care Medicine
Risk Assessment
Drug Administration Schedule
Sampling Studies
Mean difference
Magnesium Sulfate
03 medical and health sciences
Cnidarian Venoms
0302 clinical medicine
Ptosis
medicine
Animals
Humans
Bites and Stings
Prospective Studies
030212 general & internal medicine
Infusions, Intravenous
Prospective cohort study
Pain Measurement
biology
Magnesium
business.industry
Australia
030208 emergency & critical care medicine
Syndrome
medicine.disease
Carukia barnesi
biology.organism_classification
Treatment Outcome
Anesthesiology and Pain Medicine
Blood pressure
chemistry
Anesthesia
Cubozoa
Female
Irukandji syndrome
medicine.symptom
business
Subjects
Details
- ISSN :
- 14480271 and 0310057X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Anaesthesia and Intensive Care
- Accession number :
- edsair.doi.dedup.....7e45ddb444262a618adec55e1b821fe4