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Latest Update on Prevention of Acute Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients
- Source :
- Current Oncology Reports
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Purpose of Review Chemotherapy-induced nausea and vomiting (CINV) is a common cause of acute morbidity that impacts quality of life in children receiving cancer treatment. Here, we review the evolution of CINV prophylaxis guidelines in children, with an emphasis on the literature published in the last 5 years, to bring the reader up to date. Recent Findings Recent studies have led to the adoption of the “triple therapy” regimen of antiemetic prophylaxis (a 5-HT3 antagonist, dexamethasone, and a neurokinin-1 antagonist) as the backbone of recommendations for the prevention of CINV in children. Areas of new data include the addition of aprepitant and inclusion of palonosetron as a non-inferior 5-HT3 antagonist. In addition, there are emerging pediatric data informing patient-derived risk factors associated with CINV risk and classification of antineoplastic drugs based on emetogenicity. Summary Several recent pediatric studies have shaped published guidelines for CINV prophylaxis in children.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Vomiting
medicine.drug_class
Nausea
CINV
Antineoplastic Agents
Guidelines
03 medical and health sciences
0302 clinical medicine
Neoplasms
medicine
Humans
Serotonin 5-HT3 Receptor Antagonists
Antiemetic
Child
Intensive care medicine
Aprepitant
Randomized Controlled Trials as Topic
business.industry
Palonosetron
Prognosis
Pediatric cancer
humanities
Pediatric Oncology (G Tian, Section Editor)
Regimen
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Quality of Life
Antiemetics
Chemotherapy-induced nausea and vomiting
medicine.symptom
business
Supportive care
medicine.drug
Subjects
Details
- ISSN :
- 15346269 and 15233790
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Current Oncology Reports
- Accession number :
- edsair.doi.dedup.....7e3dbe47c10b777b26b59a0c34670017