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Epidemiology, Clinical Assessments, and Current Treatments of Nonunions
- Source :
- Current osteoporosis reports. 18(3)
- Publication Year :
- 2020
-
Abstract
- The failure of bony union following a fracture, termed a fracture nonunion, has severe patient morbidity and economic consequences. This review describes current consensuses and future directions of investigation for determining why, detecting when, and effective treatment if this complication occurs. Current nonunion investigation is emphasizing an expanded understanding of the biology of healing. This has led to assessments of the immune environment, multiple cytokines and morphogenetic factors, and the role of skeletogenic stem cells in the development of nonunion. Detecting biological markers and other objective diagnostic criteria is also a current objective of nonunion research. Treatment approaches in the near future will likely be dominated by the development of specific adjunct therapies to the nonunion surgical management, which will be informed by an expanded mechanistic understanding of nonunion biology. Current consensus among orthopedists is that improved diagnosis and treatment of nonunion hinges first on discoveries at the bench side with later translation to the clinic.
- Subjects :
- musculoskeletal diseases
0301 basic medicine
Fracture Healing
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Bony union
Nonunion
030209 endocrinology & metabolism
musculoskeletal system
equipment and supplies
medicine.disease
03 medical and health sciences
surgical procedures, operative
030104 developmental biology
0302 clinical medicine
Fractures, Ununited
Epidemiology
Orthopedic surgery
medicine
Effective treatment
Humans
Intensive care medicine
Economic consequences
Fracture nonunion
Subjects
Details
- ISSN :
- 15442241
- Volume :
- 18
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Current osteoporosis reports
- Accession number :
- edsair.doi.dedup.....7e3d8707f23c0670274e93882eae6c40