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Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel
- Source :
- World journal of gastroenterology. 24(35)
- Publication Year :
- 2018
-
Abstract
- To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto (DKT) associated with transient receptor potential ankyrin 1 (TRPA1) channels in intestinal myofibroblasts.Inflammatory and fibrotic changes were detected in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) chronic colitis model of wild-type and TRPA1-knockout (TRPA1-KO) miceChronic treatment with TNBS caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice. A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO mice. The active ingredients of DKT,The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis, and benefit inflammatory bowel disease treatment.
- Subjects :
- 0301 basic medicine
Daikenchuto
Adult
Male
Zanthoxylum
Colon
Panax
Intestinal fibrosis
Cell Line
03 medical and health sciences
Transient receptor potential channel
Mice
Crohn Disease
Zingiberaceae
Ankyrin
Animals
Humans
Myofibroblasts
TRPA1 Cation Channel
Da jian zhong tang
chemistry.chemical_classification
Mice, Knockout
Chemistry
Plant Extracts
Gastroenterology
General Medicine
Middle Aged
Colitis
Fibrosis
Cell biology
Disease Models, Animal
030104 developmental biology
α smooth muscle actin
Trinitrobenzenesulfonic Acid
Chronic Disease
Myofibroblast
Subjects
Details
- ISSN :
- 22192840
- Volume :
- 24
- Issue :
- 35
- Database :
- OpenAIRE
- Journal :
- World journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....7e37317dba06419f62775fb05c351191