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Gut and liver handling of interleukin-6 during liver resection in man
- Source :
- HPB, 13(5), 324-331. ELSEVIER SCI LTD
- Publication Year :
- 2011
-
Abstract
- Background: Plasma interleukin-6 (IL-6) levels increase during liver resection. The source of this IL-6 is hitherto unclear. It has been demonstrated that the hepatosplanchnic area takes up IL-6 but the role of the gut and liver is unknown. The aim of the present study was to investigate the role of the gut and liver in IL-6 homeostasis during liver surgery. Methods: Before and after partial hepatectomy, IL-6 was measured in blood sampled from the radial artery, and the hepatic and portal vein. Blood flow was measured to assess IL-6 fluxes (flow times AV-differences) across the gut, liver and hepatosplanchnic area. Results: In 22 patients undergoing liver resection, IL-6 release from the gut after transection was 90.9 (30.1) ng/min (P < 0.001), whereas net IL-6 uptake by the liver equalled 83.4 (41.7) ng/min (P < 0.01). Overall hepatosplanchnic flux was 7.3 (43.5) ng/min after transection and did not differ significantly from zero. Overall hepatosplanchnic flux was 87.8 (41.5) ng/min in the major resection group and -59.8 (67.5) ng/min in the minor resection group (P < 0.05). Discussion: The gut releases IL-6 and the liver takes up IL-6 before and after liver resection. The loss of IL-6 uptake as a result of a small functional remnant liver could lead to higher IL-6 levels after surgery.
- Subjects :
- Male
Liver surgery
Pathology
Time Factors
CLEARANCE
SURGERY
medicine.medical_treatment
Partial hepatectomy
Gastroenterology
ACUTE-PHASE PROTEINS
Homeostasis
Splanchnic Circulation
liver surgery
Aged, 80 and over
Gastrointestinal tract
biology
Portal Vein
Acute-phase protein
PARTIAL-HEPATECTOMY
HUMANS
Middle Aged
Liver
Radial Artery
Regression Analysis
Female
Blood Flow Velocity
Adult
medicine.medical_specialty
PORTAL-VEIN
Hepatic Veins
Resection
REGENERATION
Internal medicine
medicine
Hepatectomy
Interleukin 6
Aged
Hepatology
business.industry
interleukin-6
CYTOKINES
Original Articles
Gastrointestinal Tract
MICE
Regional Blood Flow
biology.protein
RAT
business
metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365182X
- Database :
- OpenAIRE
- Journal :
- HPB, 13(5), 324-331. ELSEVIER SCI LTD
- Accession number :
- edsair.doi.dedup.....7e3501bd9cd143ce99d3df904d7c2478