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CIIA negatively regulates neuronal cell death induced by oxygen–glucose deprivation and reoxygenation
- Source :
- Molecular and Cellular Biochemistry. 397:139-146
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Brain ischemia causes neuronal injury leading to stroke and other related brain diseases. However, the precise mechanism of the ischemia-induced neuronal death remains unclear yet. In this study, we showed that CIIA suppressed neuronal cell death induced by oxygen and glucose deprivation followed by reoxygenation (OGD/R), which mimics ischemia and reperfusion in vivo, in neuroblastoma cell lines as well as primary cortical neurons. Furthermore, CIIA inhibited the OGD/R-induced stimulation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream kinases including c-Jun amino-terminal kinase and p38 kinase, concomitantly blocking ASK1 homo-oligomerization and the binding between ASK1 and TRAF2. CIIA also repressed the OGD/R-induced activation of caspase-3 in neuronal cells. Taken together, our results suggest that CIIA attenuates neurotoxicity caused by OGD/R through inhibiting ASK1-dependent signaling events.
- Subjects :
- Programmed cell death
p38 mitogen-activated protein kinases
Clinical Biochemistry
Biology
MAP Kinase Kinase Kinase 5
Brain ischemia
Mice
Cell Line, Tumor
medicine
Animals
Humans
ASK1
Molecular Biology
Neurons
Cell Death
Endosomal Sorting Complexes Required for Transport
Caspase 3
Kinase
Neurotoxicity
Cell Biology
General Medicine
TNF Receptor-Associated Factor 2
medicine.disease
Cell Hypoxia
Cell biology
Oxygen
Glucose
nervous system
Biochemistry
Apoptosis
Signal transduction
Carrier Proteins
Signal Transduction
Subjects
Details
- ISSN :
- 15734919 and 03008177
- Volume :
- 397
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Biochemistry
- Accession number :
- edsair.doi.dedup.....7e2decbfe5d6893cca3bb85332620d7d