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Chemoinformatic expedition of the chemical space of fungal products
- Source :
- Future Medicinal Chemistry. 8:1399-1412
- Publication Year :
- 2016
- Publisher :
- Future Science Ltd, 2016.
-
Abstract
- Aim: Fungi are valuable resources for bioactive secondary metabolites. However, the chemical space of fungal secondary metabolites has been studied only on a limited basis. Herein, we report a comprehensive chemoinformatic analysis of a unique set of 207 fungal metabolites isolated and characterized in a USA National Cancer Institute funded drug discovery project. Results: Comparison of the molecular complexity of the 207 fungal metabolites with approved anticancer and nonanticancer drugs, compounds in clinical studies, general screening compounds and molecules Generally Recognized as Safe revealed that fungal metabolites have high degree of complexity. Molecular fingerprints showed that fungal metabolites are as structurally diverse as other natural products and have, in general, drug-like physicochemical properties. Conclusion: Fungal products represent promising candidates to expand the medicinally relevant chemical space. This work is a significant expansion of an analysis reported years ago for a smaller set of compounds (less than half of the ones included in the present work) from filamentous fungi using different structural properties.
- Subjects :
- 0301 basic medicine
Pharmacology
Molecular complexity
010405 organic chemistry
Drug discovery
Short Communication
Computational biology
Biology
Molecular Fingerprint
01 natural sciences
Combinatorial chemistry
Chemical space
0104 chemical sciences
03 medical and health sciences
030104 developmental biology
Cheminformatics
General screening
Drug Discovery
Generally recognized as safe
Molecular Medicine
Subjects
Details
- ISSN :
- 17568927 and 17568919
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Future Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....7e2b4b736267f07cf5ae1e2ef6b7c63d