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Nanocarriers enhance the transdermal bioavailability of resveratrol: In-vitro and in-vivo study
- Source :
- Colloids and Surfaces B: Biointerfaces. 148:650-656
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The aim of this study was to develop and assess the potential of nanostructured emulsion carriers for resveratrol topical application. Different compositions of resveratrol-loaded nanostructured emulsions were prepared using different types and amounts of surfactants and oily phases (isopropyl myristate and caproyl 90). The produced nanostructured emulsions were within the nanosized range 23.4-422.2nm with low viscosity range 2.15-17.53cps. The transdermal amount and deposition amount in the skin after 24 applications of resveratrol-loaded nanostructured emulsion were significantly increased about 896.2-fold and 10.2-fold respectively, when compared to the drug-saturated solution-treated group. Nanostructured emulsion containing IPM and low amounts of mixed surfactant of Tween80/Span 20 showed highest permeation capacity. In vivo study showed that the plasma concentration of resveratrol could be maintained at high levels for a long time after topical application of drug-loaded nanostructured emulsion. The histological examination demonstrated that the free drug- and drug-loaded nanostructured emulsion demonstrated considerably less irritation than the standard irritation group (0.8% paraformaldehyde-treated). The residual contents of resveratrol in the tested formulations after 3 months of storage at 25°C and 40°C were more than 99.97±3.90%. The results of present work confirm the high potential of nanostructured emulsion as carriers for drug topical application.
- Subjects :
- Skin Absorption
Biological Availability
02 engineering and technology
Resveratrol
Administration, Cutaneous
030226 pharmacology & pharmacy
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Colloid and Surface Chemistry
Drug Stability
Pulmonary surfactant
Stilbenes
Animals
Particle Size
Physical and Theoretical Chemistry
Isopropyl myristate
Skin
Skin Tests
Transdermal
Drug Carriers
Chromatography
Viscosity
Anti-Inflammatory Agents, Non-Steroidal
Surfaces and Interfaces
General Medicine
Permeation
021001 nanoscience & nanotechnology
Nanostructures
Bioavailability
chemistry
Emulsion
Thermodynamics
Emulsions
Nanocarriers
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 09277765
- Volume :
- 148
- Database :
- OpenAIRE
- Journal :
- Colloids and Surfaces B: Biointerfaces
- Accession number :
- edsair.doi.dedup.....7e1fd2d6608955fb451b33c398898c66