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Serum Lipid Profile in Subjects with Traumatic Spinal Cord Injury
- Source :
- Repisalud, Instituto de Salud Carlos III (ISCIII), PLoS ONE, Biblos-e Archivo. Repositorio Institucional de la UAM, instname, PLoS ONE, Vol 10, Iss 2, p e0115522 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLOS), 2015.
-
Abstract
- Background and Aims Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample for the Spanish population (DRECE study). Materials and Methods A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex. Results Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4]mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3]mg/dL LDL-c) (all p<br />Dr. Laclaustra was supported in part by grants FIS CP08/00112 and PI10/00021 from the Spanish Instituto de Salud Carlos III. Dr. Castellote was supported in part by grants TPY 1115/07, PI13/ 00526, TPY 1444/08 and ESVI 1338/12-1 from the Instituto de Salud Carlos III. Dr. Hurtado was supported by Fellowship N°088-FINCyT-BDE-2014 from the Peruvian government
- Subjects :
- Male
SYMPATHETIC-NERVOUS-SYSTEM
Gastroenterology
chemistry.chemical_compound
Medicine
Degree of neurological involvement
Young adult
Spinal cord injury
Multidisciplinary
medicine.diagnostic_test
Middle Aged
Lipid profile
CATECHOLAMINES
Traumatic injury
ADIPOSE-TISSUE
Female
lipids (amino acids, peptides, and proteins)
Research Article
Adult
medicine.medical_specialty
Adolescent
Traumatic spinal cord injury
Medicina
Science
PARTICIPATION
EXERCISE
HEART-DISEASE
Young Adult
Internal medicine
Humans
RESTING METABOLIC-RATE
Spinal Cord Injuries
Triglycerides
Retrospective Studies
Ldl cholesterol
business.industry
Cholesterol
Cholesterol, HDL
CARDIOVASCULAR-DISEASE RISK
PARAPLEGIA
Retrospective cohort study
Cholesterol, LDL
medicine.disease
Surgery
INDIVIDUALS
chemistry
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repisalud, Instituto de Salud Carlos III (ISCIII), PLoS ONE, Biblos-e Archivo. Repositorio Institucional de la UAM, instname, PLoS ONE, Vol 10, Iss 2, p e0115522 (2015)
- Accession number :
- edsair.doi.dedup.....7e1184db2b76c78923cbcdbc29c5029c