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Novel Oligo-Guanidyl-PEG Carrier Forming Rod-Shaped Polyplexes
- Source :
- Molecular Pharmaceutics. 16:1678-1693
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- A novel unconventional supramolecular oligo-cationic structure (Agm6-M-PEG-OCH3) has been synthesized to yield high efficiency therapeutic oligonucleotide (ON) delivery. Agm6-M-PEG-OCH3 was obtaine...
- Subjects :
- oligonucleotides delivery
Polymers
Oligonucleotides
Supramolecular chemistry
Pharmaceutical Science
Nanoparticle
macromolecular substances
02 engineering and technology
030226 pharmacology & pharmacy
Polyethylene Glycols
03 medical and health sciences
0302 clinical medicine
Neoplasms
Drug Discovery
PEG ratio
Tumor Cells, Cultured
Humans
Guanidine
Cell Proliferation
Drug Carriers
Oligonucleotide
Chemistry
Drug Discovery3003 Pharmaceutical Science
cationic carriers
technology, industry, and agriculture
polyplexes
021001 nanoscience & nanotechnology
Combinatorial chemistry
Nanostructures
nanoparticles
nonviral carriers
Molecular Medicine
3003
Yield (chemistry)
0210 nano-technology
Subjects
Details
- ISSN :
- 15438392 and 15438384
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular Pharmaceutics
- Accession number :
- edsair.doi.dedup.....7e1023e674d21f1bd26c4eb8cd5e8fd1
- Full Text :
- https://doi.org/10.1021/acs.molpharmaceut.9b00014