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Overexpression of interleukin-1? and interleukin-6 may play an important role in periodontal breakdown in type 2 diabetic patients
- Source :
- Journal of Periodontal Research. 42:377-381
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Background and objective This study evaluated whether the biochemical changes associated with type 2 diabetes modulate the expression of interleukin-1beta, interleukin-6, interleukin-8, and interferon-gamma in sites with chronic periodontitis. Material and methods Biopsies were harvested and divided into three groups: group 1, systemically and periodontally healthy subjects (n = 10); group 2, systemically healthy subjects with moderate-to-severe chronic periodontitis (probing depth > 6 mm) (n = 20); and group 3, type 2 diabetic subjects with periodontitis (n = 20). Cytokine levels were assessed in the gingival tissues by enzyme-linked immunosorbent assay analysis. Results Data analysis demonstrated that the interleukin-1beta, interleukin-6, interleukin-8, and interferon-gamma levels were higher in the presence of periodontal inflammation than in the absence of inflammation, regardless of systemic status. The interleukin-1beta and interleukin-6 levels were higher in diabetic subjects (group 3) than in systemically healthy patients with comparable types of periodontitis (group 2). No difference was observed for the interleukin-8 and interferon-gamma levels between groups 2 and 3. Conclusion Within the limits of this study, it was concluded that type 2 diabetes was associated with increased expression of interleukin-1beta and interleukin-6 in periodontally inflamed tissues of diabetic patients, relative to nondiabetic subjects, and that such overexpression may be involved in the mechanisms by which type 2 diabetes enhances periodontal destruction.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Interleukin-1beta
Dental Plaque
Gingiva
Enzyme-Linked Immunosorbent Assay
Inflammation
Type 2 diabetes
Dental plaque
Gastroenterology
Interferon-gamma
Diabetes mellitus
Internal medicine
medicine
Humans
Interleukin 6
Periodontal Diseases
Periodontitis
biology
Interleukin-6
business.industry
Interleukin-8
medicine.disease
Chronic periodontitis
Surgery
Cytokine
Diabetes Mellitus, Type 2
Chronic Disease
biology.protein
Periodontics
Female
Periodontal Index
medicine.symptom
business
Subjects
Details
- ISSN :
- 16000765 and 00223484
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Journal of Periodontal Research
- Accession number :
- edsair.doi.dedup.....7e0a9e341eb6d18e04e4e20b7181c068