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Altered Autonomic Nervous System Reactivity to Pain in Trigeminal Neuralgia
- Source :
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 42:125-131
- Publication Year :
- 2015
- Publisher :
- Cambridge University Press (CUP), 2015.
-
Abstract
- Background: In the past two decades, there has been increasing evidence to suggest that trigeminal neuralgia (TN) may be linked to a dysfunction of the autonomic nervous system (ANS). The aim of the present study was to formally test this hypothesis by comparing the reactivity of the ANS to experimental pain in a population of TN patients and healthy controls. Methods: Twelve patients diagnosed with classical TN and 12 healthy controls participated in the study. Cardiac activity was assessed while participants were instructed to rest and again during a cold pressor test (CPT). Heart rate variability analyses were performed off-line to obtain parasympathetic (high-frequency) and sympathetic (low-frequency) indices. Results: At baseline, ANS measures did not differ between healthy controls and TN patients, and both groups showed a similar increase in heart rate during the CPT (all p values >0.05). However, TN patients showed a greater increase in cardiac sympathetic activity and a greater decrease in cardiac parasympathetic activity during CPT compared with healthy controls (all p values Conclusions: These results suggest that TN, like many other short-lasting, unilateral facial pain conditions, is linked to ANS alterations. Future studies are required to determine if the altered ANS response observed in TN patients is a cause or a consequence of TN pain
- Subjects :
- Male
Sympathetic Nervous System
Population
Pain
Autonomic Nervous System
Facial Pain
Heart Rate
Parasympathetic Nervous System
Negatively associated
Trigeminal neuralgia
Heart rate
Pressure
Humans
Heart rate variability
Medicine
education
Reactivity (psychology)
Aged
education.field_of_study
business.industry
Cold pressor test
Heart
Pain Perception
General Medicine
Middle Aged
Trigeminal Neuralgia
medicine.disease
Cold Temperature
Autonomic nervous system
Neurology
Anesthesia
Female
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 20570155 and 03171671
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Accession number :
- edsair.doi.dedup.....7dfde8ac98c2451b7436f0fb046dab7a