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Experimental animal models of central nervous system tuberculosis: A historical review
- Source :
- Tuberculosis (Edinburgh, Scotland). 110
- Publication Year :
- 2017
-
Abstract
- Animal models are and will remain valuable tools in medical research because their use enables a deeper understanding of disease development, thus generating important knowledge for developing disease control strategies. Central nervous system tuberculosis (CNS TB) is the most devastating disease in humans. Moreover, as the variability of signs and symptoms delay a timely diagnosis, patients usually arrive at the hospital suffering from late stage disease. Therefore, it is impossible to obtain fresh human tissue for research before an autopsy. Because of these reasons, studies on human CNS TB are limited to case series, pharmacological response reports, and post mortem histopathological studies. Here, we review the contribution of the different animal models to understand the immunopathology of the disease and the host-parasitic relationship, as well as in the development of new strategies of vaccination and to test new drugs for the treatment of CNS TB.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Tuberculosis
030106 microbiology
Immunology
Central nervous system
Antitubercular Agents
Autopsy
Disease
Microbiology
03 medical and health sciences
Immunopathology
medicine
Animals
Intensive care medicine
Tuberculosis Vaccines
business.industry
Experimental Animal Models
Tuberculosis, Central Nervous System
Medical research
medicine.disease
Vaccination
Disease Models, Animal
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
business
Subjects
Details
- ISSN :
- 1873281X
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Tuberculosis (Edinburgh, Scotland)
- Accession number :
- edsair.doi.dedup.....7dfce65fbc2b7cbec310a2b0f1bfa70e