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Prediction of the epichlorohydrin derived cytotoxic substances from the eluent of poly(glycerol glycidyl ether) films
- Source :
- Zhou, S.; Xu, X.; Ma, N.; Jung, F.; Lendlein, A.: Prediction of the epichlorohydrin derived cytotoxic substances from the eluent of poly(glycerol glycidyl ether) films. In: MRS Advances . Vol. 7 (2022) 354-359. (DOI: /10.1557/s43580-021-00132-y)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Glycerol-based epoxy networks have great potential for surface functionalization, providing anti-microbial and protein repellant function. However, the synthesis of glycerol glycidyl ether (GGE) monomer often requires excessive epichlorohydrin (ECH). ECH derived organochloride containing byproducts from monomer production maybe present in the eluent of the polymer networks prepared by cationic ring-opening polymerization. Here, the cytotoxicity analysis revealed cell damages in contact with the polyGGE eluent. The occurrence of organochlorides, which was predicted based on the data from high-performance liquid chromatography/electrospray ionization mass spectrometry, as confirmed by a constant chloride level in GGE and polyGGE, and by a specific peak of C–Cl in infrared spectra of GGE. The resulting polyGGE was densely crosslinked, which possibly contribute to the trapping of organochlorides. These results provide a valuable information for exploring the toxins leaching from polyGGE and propose a feasible strategy for minimizing the cytotoxicity via reducing their crosslink density. Graphic abstract The eluent of poly(glycerol glycidyl ether) (polyGGE) films impaired the viability and metabolic activity of L-929 cells due to the organochloride byproducts or epichlorohydrin precursors originating from the GGE monomer, which was predicted based on the data from high-performance liquid chromatography/electrospray ionization mass spectrometry (HPLC–ESI–MS) and confirmed by chloride content analysis and attenuated total reflection fourier transform infrared (ATR-FT-IR) spectroscopy.
- Subjects :
- glycerol glycidyl ether derived organochloride
Chromatography
Materials science
Mechanical Engineering
Electrospray ionization
Cationic polymerization
prediction
Organochloride
cytotoxicity analysis
Condensed Matter Physics
chemistry.chemical_compound
Column chromatography
Monomer
chemistry
Polymerization
Mechanics of Materials
Glycerol
General Materials Science
Epichlorohydrin
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
Subjects
Details
- ISSN :
- 20598521
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- MRS Advances
- Accession number :
- edsair.doi.dedup.....7dfbe3b35cbe0e699417ad56273aaa6d