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Complete regression of colonic adenomas after treatment with sulindac in Gardner's syndrome: a 4-year follow-up
- Source :
- Journal of Gastroenterology. 36:778-782
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- A 22-year-old woman with Gardner's syndrome in whom long-term sulindac therapy, without surgical treatment, was effective in inducing complete regression of colonic adenomas is reported. One hundred milligrams of sulindac was administered twice daily after endoscopic polypectomy. Follow-up colonoscopy 6 months later revealed an encouraging regression of colonic adenomas. The tumors had disappeared after 40 months of sulindac treatment. A sustained effect was identified even after 51 months. Ten milligrams of famotidine was coadministered to prevent side effects of sulindac. Although the effect of sulindac on colorectal adenomas may be transient, this therapy may be useful for postponing prophylactic colectomy, especially for the sparse type of familial adenomatous polyposis.
- Subjects :
- Adenoma
Adult
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Colonoscopy
Antineoplastic Agents
Gastroenterology
Familial adenomatous polyposis
Sulindac
Surgical oncology
Internal medicine
Humans
Medicine
Gardner Syndrome
Colectomy
medicine.diagnostic_test
business.industry
Remission Induction
Skull
Hepatology
medicine.disease
digestive system diseases
Colorectal surgery
Radiography
Gardner's syndrome
Colonic Neoplasms
Female
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 14355922 and 09441174
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....7de10ebf62e901445d9e9347b492b987