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Topical corticosteroid allergy: Results of sequential testing to a corticosteroid series in New Zealand
- Source :
- Contact Dermatitis. 85:32-38
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background Our institution tests the European Baseline Series (EBS) and a steroid series sequentially in all patients presenting for patch testing. The rate of steroid sensitization in New Zealand has not previously been documented. Objectives To investigate the rate of corticosteroid sensitization and assess additional benefit of testing the full steroid series over the steroid allergy markers in the EBS. Methods/patients Retrospective analysis of all patient demographics and patch test results over a 5-year period (2014 to 2019) was performed at a tertiary patch test clinic in Auckland, New Zealand. Results A total of 319 patients completed patch testing, and 4.4% were sensitized to one or more corticosteroids. As much as 79% of positive reactions were of current relevance; 11/14 reactions were to tixocortol pivalate or budesonide. The "number needed to test" to detect one additional case of corticosteroid sensitization by using the full corticosteroid series over the EBS alone was 107. Conclusions Although corticosteroid sensitization was not uncommon in our population, the results suggest that sequential testing with the corticosteroid markers (budesonide and tixocortol) in the standard series alone is adequate. The additional corticosteroid series should be added if the markers are positive or where there is a clinical suspicion of corticosteroid allergy.
- Subjects :
- Adult
Male
Budesonide
medicine.medical_specialty
Adolescent
medicine.drug_class
Administration, Topical
Population
Dermatology
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Adrenal Cortex Hormones
Tixocortol pivalate
medicine
Humans
Immunology and Allergy
030212 general & internal medicine
education
Sensitization
Aged
Retrospective Studies
education.field_of_study
business.industry
Patch test
Atopic dermatitis
Middle Aged
Patch Tests
medicine.disease
medicine.anatomical_structure
Dermatitis, Occupational
chemistry
Tixocortol
Dermatitis, Allergic Contact
Corticosteroid
Female
business
New Zealand
medicine.drug
Subjects
Details
- ISSN :
- 16000536 and 01051873
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Contact Dermatitis
- Accession number :
- edsair.doi.dedup.....7ddc75091b8bf9898c73cbfae3d7fe79
- Full Text :
- https://doi.org/10.1111/cod.13776