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The frontotemporal region plays a role in the genesis of migraine without aura
- Source :
- Headache. 35(3)
- Publication Year :
- 1995
-
Abstract
- We have compared the migraine-inducing effect of nitroglycerin ointment applied to the frontotemporal region of the head, which is innervated by the ophthalmic and maxillary divisions of the trigeminal nerve, with that of nitroglycerin applied to the chin (innervated by the mandibular division), the posterolateral region of the neck (innervated by the second and third cervical roots), the lateral surface of the proximal third of the forearm (innervated by the sixth cervical root), and the medial surface of the upper-arm region (second dorsal root). One hundred patients suffering from migraine without aura were randomly divided into five equal groups. Each group received an application of 5 mg nitroglycerin in 2% ointment on a preselected body area for 2 hours. Frontotemporal nitroglycerin induced a significantly greater number of early onset migraine attacks with respect to the arm and forearm regions. In all cases, nitroglycerin applied to the frontotemporal region resulted in subsequent migraine, whereas there was a significant number of negative trials with nitroglycerin applied to the neck, arm, and forearm vs the frontotemporal area. It, therefore, appears that the trigeminal nerve endings in the affected frontotemporal region are particularly sensitive to the migraine-inducing effect of the nitrate. This suggests a peripheral neurogenic hypothesis of migraine genesis.
- Subjects :
- Adult
Male
Chin
Adolescent
Aura
Migraine Disorders
Central nervous system disease
Ointments
Nitroglycerin
Forearm
medicine
Humans
Trigeminal nerve
Vascular disease
business.industry
Middle Aged
medicine.disease
Temporal Lobe
Peripheral
Frontal Lobe
medicine.anatomical_structure
Neurology
Migraine
Anesthesia
Arm
Female
Neurology (clinical)
business
Neck
Subjects
Details
- ISSN :
- 00178748
- Volume :
- 35
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Headache
- Accession number :
- edsair.doi.dedup.....7dd13e871bc8ebc5b76a8b2a073100f6