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Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries
- Source :
- FEBS letters. 588(17)
- Publication Year :
- 2014
-
Abstract
- Extracellular UDP-glucose can activate the purinergic P2Y14 receptor. The aim of the present study was to examine the physiological importance of P2Y14 receptors in the vasculature. The data presented herein show that UDP-glucose causes contraction in mouse coronary and basilar arteries. The EC50 values and immunohistochemistry illustrated the strongest P2Y14 receptor expression in the basilar artery. In the presence of pertussis toxin, UDP-glucose inhibited contraction in coronary arteries and in the basilar artery it surprisingly caused relaxation. After organ culture of the coronary artery, the EC50 value decreased and an increased staining for the P2Y14 receptor was observed, showing receptor plasticity.
- Subjects :
- Male
Uridine Diphosphate Glucose
Pathology
medicine.medical_specialty
Receptor expression
Cerebral arteries
Biophysics
In Vitro Techniques
Coronary artery
Pertussis toxin
Biochemistry
Mice
Structural Biology
medicine.artery
Genetics
Basilar artery
medicine
Animals
P2Y14
Receptor
Molecular Biology
Receptor upregulation
Mice, Inbred BALB C
business.industry
Purinergic receptor
Cell Biology
Anatomy
Cerebral Arteries
Coronary Vessels
Up-Regulation
Coronary arteries
medicine.anatomical_structure
Pertussis Toxin
P2Y2 KO
Receptors, Purinergic P2Y
Female
Purinergic receptors
business
Artery
Muscle Contraction
Subjects
Details
- ISSN :
- 18733468
- Volume :
- 588
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....7dc9a323c56fb1fb2ac9f4597772ba2f