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Rapid synthesis of microwave-assisted zinc oxide nanorods on a paper-based analytical device for fluorometric detection of l-dopa
- Source :
- Colloids and Surfaces B: Biointerfaces. 207:111995
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- l-dopa is a catecholamine neurotransmitter used to treat Parkinson's disease. This paper presents a low-cost paper-based biosensor aimed at enhancing the convenience of monitoring l-dopa concentrations. ZnO nanorods (ZnO-NRs) were synthesized on papers in less than 90 min using a microwave-assisted hydrothermal method. The ZnO-NRs amplify green fluorescence signals to enhance the detection sensitivity of l-dopa, best measured at excitation/emission wavelengths of 475/537 nm. We systematically characterized the effect of reaction conditions on the corresponding fluorescence enhancements. The proposed ZnO NRs-paper biosensor presented a ∼3-fold increase in green fluorescence compared to unmodified papers. The linear range of detection for l-dopa was 25-2000 nM, with a limit of detection of 24 nM, which meets the clinical requirements for the monitoring of l-dopa in Parkinson's patients.
- Subjects :
- Detection limit
Nanotubes
Materials science
business.industry
chemistry.chemical_element
Biosensing Techniques
Surfaces and Interfaces
General Medicine
Zinc
Paper based
Microwave assisted
Fluorescence
Levodopa
Colloid and Surface Chemistry
Linear range
chemistry
Humans
Optoelectronics
Nanorod
Zinc Oxide
Physical and Theoretical Chemistry
Microwaves
business
Biosensor
Biotechnology
Subjects
Details
- ISSN :
- 09277765
- Volume :
- 207
- Database :
- OpenAIRE
- Journal :
- Colloids and Surfaces B: Biointerfaces
- Accession number :
- edsair.doi.dedup.....7db90f7aa9d59411028b2b47269621ed