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An evaluation of liposome-based diagnostics of pulmonary and extrapulmonary tuberculosis
- Source :
- Expert Review of Molecular Diagnostics. 20:533-541
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Introduction: Tuberculosis (TB) is still one of the major global health threats and delayed diagnosis or misdiagnosis continues to fuel the global epidemic. The conventional diagnostic approaches have shortcomings that might hinder the process of diagnosis of the disease and ultimately affect the prognosis.Area covered: We emphasize on the process of the synthesis of liposomes, its physicochemical properties affecting the formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a light on other nanoparticle-based molecular diagnostic approaches for TB. Despite the advent of science, we are yet to have a diagnostic tool that is simple, rapid, sensitive, and specific, and most importantly, one that enables us to demarcate patients with active tuberculosis from those with quiescent lesions, prior vaccination, or other diseases.Expert opinion: The utility of liposomes for diagnostic purposes has been attempted so as to overcome the challenges posed by conventional diagnostic tools for TB. Through this review, we present insights into liposome formulation and selection processes, various studies that report the use of liposome-based diagnostic tools for TB, as well as the limitations associated with the same that can be improvised to make the technology more efficient.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Tuberculosis
Disease
Diagnostic tools
Sensitivity and Specificity
Theranostic Nanomedicine
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Genetics
medicine
Global health
Humans
Intensive care medicine
Tuberculosis, Pulmonary
Molecular Biology
Liposome
business.industry
Extrapulmonary tuberculosis
Mycobacterium tuberculosis
medicine.disease
Molecular diagnostics
Active tuberculosis
030104 developmental biology
Molecular Diagnostic Techniques
030220 oncology & carcinogenesis
Liposomes
Nanoparticles
Molecular Medicine
business
Subjects
Details
- ISSN :
- 17448352 and 14737159
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Expert Review of Molecular Diagnostics
- Accession number :
- edsair.doi.dedup.....7db65bd6ac5b9d1f4974c651a943ee43