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Clinical features of paediatric and adult autoimmune encephalitis: A multicenter sample
- Source :
- European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 30
- Publication Year :
- 2020
-
Abstract
- Autoimmune encephalitis (AE) is a heterogeneous class of inflammatory diseases of the brain that can present with a wide spectrum of neuropsychiatric symptoms. Patients may be negative for CSF anti-neuronal antibodies, which can make the diagnosis of AE challenging. Distinguishing features between paediatric and adult patients with AE are not well characterized.Describe the clinical presentation, seizure type, EEG and sleep patterns in paediatric and adult patients with AE.Retrospective review of clinical data from paediatric and adult patients diagnosed with AE from three medical centers between 1/2008-12/2019.We included 100 patients with AE, including 65 children. Median age at presentation was 14 years (1-88years). Fifty-five patients had positive CSF autoantibody results (NMDAR 36%, VGKC Ab 10%, anti-GAD65 4%, miscellaneous 3%), and 47 patients were autoantibody-negative. Paediatric patients were more likely to present with psychiatric symptoms, focal seizures and/or status epilepticus, and sleep disturbances compared to adult patients (p 0.05). There was a higher incidence of NMDA-R encephalitis in children compared to adults.Paediatric patients with AE were more likely to present with psychiatric symptoms, sleep disturbances, focal seizures, and/or status epilepticus compared to adults (p 0.05). Insomnia and hypersomnia are common sleep problems associated with AE that should be screened early in the diagnostic evaluation. Further studies can be performed to explore the relationship between sleep disturbances and long-term cognitive effects and the incidence of chronic epilepsy in this subset of patients.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Status epilepticus
Electroencephalography
Autoimmune Diseases
03 medical and health sciences
Epilepsy
Young Adult
0302 clinical medicine
030225 pediatrics
Medicine
Humans
Child
Paediatric patients
Aged
Retrospective Studies
Autoimmune encephalitis
Aged, 80 and over
Adult patients
medicine.diagnostic_test
business.industry
Autoantibody
General Medicine
Middle Aged
medicine.disease
Sleep patterns
Child, Preschool
Pediatrics, Perinatology and Child Health
Encephalitis
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15322130
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
- Accession number :
- edsair.doi.dedup.....7db430ff5013f3ff6087544ab5e6dfff