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A longitudinal neurite and free water imaging study in patients with a schizophrenia spectrum disorder
- Source :
- Neuropsychopharmacology
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Diffusion tensor imaging (DTI) studies show widespread white matter abnormalities in schizophrenia, but it is difficult to directly relate these parameters to biological processes. Neurite orientation dispersion and density imaging (NODDI) is geared toward biophysical characterization of white matter microstructure, but only few studies have leveraged this technique to study white matter alterations. We recruited 42 schizophrenia patients (30 antipsychotic-naïve and 12 currently untreated) and 42 matched controls in this prospective study. We assessed the orientation dispersion index (ODI) and extracellular free water (FW) using single-shell DTI data before and after a 6-week trial of risperidone. Longitudinal data were available for 27 patients. Voxelwise analyses showed significantly increased ODI in the posterior limb of the internal capsule in unmedicated patients (242 voxels; x = −24; y = 6; z = 6; p
- Subjects :
- Adult
Male
medicine.medical_specialty
Internal capsule
Adolescent
Neurite
computer.software_genre
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
Voxel
Internal medicine
Neurites
medicine
Humans
Longitudinal Studies
Prospective Studies
Prospective cohort study
Pharmacology
Risperidone
business.industry
Brain
medicine.disease
White Matter
030227 psychiatry
Psychiatry and Mental health
Diffusion Tensor Imaging
Schizophrenia
Cardiology
Biomarker (medicine)
Female
business
computer
030217 neurology & neurosurgery
Diffusion MRI
medicine.drug
Subjects
Details
- ISSN :
- 1740634X and 0893133X
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....7da911be3202ae4748df9fc3a893671f