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Diminution of N-methyl-d-aspartate-induced perturbation of neurotransmission by dexmedetomidine in the CA1 field of rat hippocampus in vitro
- Source :
- Neuroscience Letters. 281:95-98
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- The effects of α 2 -adrenoceptor activation on N -methyl- d -aspartic acid (NMDA)-induced perturbation of neurotransmission and normal NMDA-receptor dependent function (long-term potentiation, (LTP)) were investigated in the hippocampal CA1 field in vitro. Bath perfusion of dexmedetomidine hydrochloride (50 nM), which was initiated before NMDA (100 μM) exposure, enhanced the extent of recovery of extracellular field excitatory postsynaptic potentials after NMDA infusion. On the other hand, the induction and early maintenance of LTP was normal in the presence of dexmedetomidine. Thus, dexmedetomidine can diminish acute NMDA-induced perturbation of neurotransmission while the same dose of this drug does not influence the normal activation of NMDA receptors.
- Subjects :
- Male
Agonist
medicine.medical_specialty
N-Methylaspartate
medicine.drug_class
Long-Term Potentiation
In Vitro Techniques
Hippocampal formation
Neurotransmission
Hippocampus
Receptors, N-Methyl-D-Aspartate
Synaptic Transmission
Receptors, Adrenergic, alpha-2
Internal medicine
Excitatory Amino Acid Agonists
medicine
Animals
Rats, Wistar
Dexmedetomidine
Chemistry
General Neuroscience
Glutamate receptor
Excitatory Postsynaptic Potentials
Long-term potentiation
Rats
Endocrinology
nervous system
Excitatory postsynaptic potential
NMDA receptor
Adrenergic alpha-Agonists
medicine.drug
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 281
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....7d9b205b0ff8bf92f587dc70871bf435