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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
- Source :
- Nature Genetics, 42(12), 1118, Nature genetics, 42(12), 1118-1125. Nature Publishing Group, Franke, A, McGovern, D P B, Barrett, J C, Wang, K, Radford-Smith, G L, Ahmad, T, Lees, C W, Balschun, T, Lee, J, Roberts, R, Anderson, C A, Bis, J C, Bumpstead, S, Ellinghaus, D, Festen, E M, Georges, M, Green, T, Haritunians, T, Jostins, L, Latiano, A, Mathew, C G, Montgomery, G W, Prescott, N J, Raychaudhuri, S, Rotter, J I, Schumm, P, Sharma, Y, Simms, L A, Taylor, K D, Whiteman, D, Wijmenga, C, Baldassano, R N, Barclay, M, Bayless, T M, Brand, S, Buening, C, Cohen, A, Colombel, J-F, Cottone, M, Stronati, L, Denson, T, De Vos, M, D'Inca, R, Dubinsky, M, Edwards, C, Florin, T, Franchimont, D, Gearry, R, Glas, J, Van Gossum, A, Guthery, S L, Halfvarson, J, Verspaget, H W, Hugot, J-P, Karban, A, Laukens, D, Lawrance, I, Lemann, M, Levine, A, Libioulle, C, Louis, E, Mowat, C, Newman, W, Panes, J, Phillips, A, Proctor, D D, Regueiro, M, Russell, R, Rutgeerts, P, Sanderson, J, Sans, M, Seibold, F, Steinhart, A H, Stokkers, P C F, Torkvist, L, Kullak-Ublick, G, Wilson, D, Walters, T, Targan, S R, Brant, S R, Rioux, J D, D'Amato, M, Weersma, R K, Kugathasan, S, Griffiths, A M, Mansfield, J C, Vermeire, S, Duerr, R H, Silverberg, M S, Satsangi, J, Schreiber, S, Cho, J H, Annese, V, Hakonarson, H, Daly, M J & Parkes, M 2010, ' Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci ', Nature Genetics, vol. 42, no. 12, pp. 1118-1125 . https://doi.org/10.1038/ng.717, Nature Genetics, 42(12), 1118-+. Nature Publishing Group, Nature genetics
- Publication Year :
- 2010
-
Abstract
- We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 x 10(-8)). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
- Subjects :
- Candidate gene
Genetic Linkage
PROTEIN
Genome-wide association study
Inflammatory bowel disease
Genome
ACTIVATION
0302 clinical medicine
Crohn Disease
SEQUENCE VARIANTS
Genetics
0303 health sciences
NEDD4 FAMILY
COMMON VARIANTS
ASSOCIATION
3. Good health
030220 oncology & carcinogenesis
10076 Center for Integrative Human Physiology
Computational Biology
Genetic Loci
Genetic Variation
Genome, Human
Humans
Reproducibility of Results
Genetic Predisposition to Disease
Genome-Wide Association Study
inflammatory-bowel-disease sequence variants common variants nedd4 family association gene identification receptor protein activation
Human
Locus (genetics)
610 Medicine & health
Biology
03 medical and health sciences
1311 Genetics
Genetic linkage
medicine
030304 developmental biology
Genetic association
IDENTIFICATION
RECEPTOR
medicine.disease
GENE
Settore MED/03 - Genetica Medica
10199 Clinic for Clinical Pharmacology and Toxicology
570 Life sciences
biology
Human genome
genome-wide scan.meta-analysis.crohn's disease
INFLAMMATORY-BOWEL-DISEASE
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, 42(12), 1118, Nature genetics, 42(12), 1118-1125. Nature Publishing Group, Franke, A, McGovern, D P B, Barrett, J C, Wang, K, Radford-Smith, G L, Ahmad, T, Lees, C W, Balschun, T, Lee, J, Roberts, R, Anderson, C A, Bis, J C, Bumpstead, S, Ellinghaus, D, Festen, E M, Georges, M, Green, T, Haritunians, T, Jostins, L, Latiano, A, Mathew, C G, Montgomery, G W, Prescott, N J, Raychaudhuri, S, Rotter, J I, Schumm, P, Sharma, Y, Simms, L A, Taylor, K D, Whiteman, D, Wijmenga, C, Baldassano, R N, Barclay, M, Bayless, T M, Brand, S, Buening, C, Cohen, A, Colombel, J-F, Cottone, M, Stronati, L, Denson, T, De Vos, M, D'Inca, R, Dubinsky, M, Edwards, C, Florin, T, Franchimont, D, Gearry, R, Glas, J, Van Gossum, A, Guthery, S L, Halfvarson, J, Verspaget, H W, Hugot, J-P, Karban, A, Laukens, D, Lawrance, I, Lemann, M, Levine, A, Libioulle, C, Louis, E, Mowat, C, Newman, W, Panes, J, Phillips, A, Proctor, D D, Regueiro, M, Russell, R, Rutgeerts, P, Sanderson, J, Sans, M, Seibold, F, Steinhart, A H, Stokkers, P C F, Torkvist, L, Kullak-Ublick, G, Wilson, D, Walters, T, Targan, S R, Brant, S R, Rioux, J D, D'Amato, M, Weersma, R K, Kugathasan, S, Griffiths, A M, Mansfield, J C, Vermeire, S, Duerr, R H, Silverberg, M S, Satsangi, J, Schreiber, S, Cho, J H, Annese, V, Hakonarson, H, Daly, M J & Parkes, M 2010, ' Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci ', Nature Genetics, vol. 42, no. 12, pp. 1118-1125 . https://doi.org/10.1038/ng.717, Nature Genetics, 42(12), 1118-+. Nature Publishing Group, Nature genetics
- Accession number :
- edsair.doi.dedup.....7d9aa7ac69972e7d9ecc112096177ff1