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A systematic review and meta-analysis of cross-reactivity of antibodies induced by H7 influenza vaccine
- Source :
- Human Vaccines & Immunotherapeutics
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Inoculation with vaccine is the major intervention currently used to prevent influenza infections. However, it will be a challenge to produce and implement a new vaccine when a novel highly pathogenic influenza virus emerges in humans as significant infections. H7 subtype influenza viruses have similar epitopes on hemagglutinin, which can induce cross-reactive antibodies. In this study, a meta-analysis of the cross-reactivity of antibodies induced by one H7 subtype influenza vaccine against other H7 subtypes was performed. Database search was conducted in PubMed, Cochrane Library, EMBASE, MEDLINE, Chinese Biological Medicine Database (CBM), and Wanfang. A total of 9 articles comprising 811 human subjects were included in this meta-analysis. All assessed H7 influenza vaccines induced vaccine strain-specific protective antibodies [seroconversion rate (SCR) = 0.74, 95% CI (0.65, 0.82); seroprotection rate (SPR) = 0.81, 95% CI (0.78, 0.83)]. All H7 influenza virus monovalent vaccines exhibited cross-reactivity tested by hemagglutinin inhibition test (HI), microneutralization test (MN) and immunosorbent assay (ELISA) to other H7 subtype viruses. H7N1, H7N3, H7N7, and H7N9 vaccines elicited cross-reactive antibodies against other H7 subtype influenza viruses [SCR = 0.66, 95% CI (0.50, 0.82); SPR = 0.79, 95% CI (0.67, 0.91)]. The pooled SCR (95%CI) of cross-reactivity of H7N1 and H7N3 vaccines were 0.88 (0.85, 0.91) and 0.40 (0.26, 0.54), respectively. The consolidated SPR (95%CI) of H7N1 and H7N7 vaccines were 0.89 (0.86, 0.92) and 0.93 (0.81, 1.06). All H7 vaccines induced cross-reactive antibodies against H7N9 viruses [SCR = 0.69, 95% CI (0.52, 0.86); SPR = 0.85, 95% CI (0.76, 0.94)]. H7 vaccines can be used to limit influenza infection when a new highly pathogenic H7 virus appears.
- Subjects :
- Influenza vaccine
030231 tropical medicine
Immunology
Influenza A Virus, H7N7 Subtype
Hemagglutinin (influenza)
Hemagglutinin Glycoproteins, Influenza Virus
Antibodies, Viral
Influenza A Virus, H7N9 Subtype
medicine.disease_cause
Cross-reactivity
Virus
Epitope
Influenza A Virus, H7N3 Subtype
03 medical and health sciences
0302 clinical medicine
systematic review
vaccine
Influenza, Human
Humans
Immunology and Allergy
Medicine
030212 general & internal medicine
Seroconversion
Pharmacology
biology
business.industry
Antibodies, Neutralizing
Virology
meta-analysis
Influenza Vaccines
Meta-analysis
biology.protein
Influenza A Virus, H7N1 Subtype
Antibody
business
H7 subtype
Research Paper
Subjects
Details
- ISSN :
- 2164554X and 21645515
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Human Vaccines & Immunotherapeutics
- Accession number :
- edsair.doi.dedup.....7d764d62673315c771309a95b03acbec