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Brain age in bipolar disorders: Effects of lithium treatment
- Source :
- Australian & New Zealand Journal of Psychiatry. 53:1179-1188
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- Objective:Bipolar disorders increase the risk of dementia and show biological and brain alterations, which resemble accelerated aging. Lithium may counter some of these processes and lower the risk of dementia. However, until now no study has specifically investigated the effects of Li on brain age.Methods:We acquired structural magnetic resonance imaging scans from 84 participants with bipolar disorders (41 with and 43 without Li treatment) and 45 controls. We used a machine learning model trained on an independent sample of 504 controls to estimate the individual brain ages of study participants, and calculated BrainAGE by subtracting chronological from the estimated brain age.Results:BrainAGE was significantly greater in non-Li relative to Li or control participants, F(2, 125) = 10.22, p Conclusions:Bipolar disorders were associated with greater, whereas Li treatment with lower discrepancy between brain and chronological age. These findings support the neuroprotective effects of Li, which were sufficiently pronounced to affect a complex, multivariate measure of brain structure. The association between Li treatment and BrainAGE was independent of long-term thymoprophylactic response and thus may generalize beyond bipolar disorders, to neurodegenerative disorders.
- Subjects :
- Adult
Male
Oncology
Treatment response
medicine.medical_specialty
Bipolar Disorder
Lithium (medication)
Machine Learning
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
Dementia
business.industry
Age Factors
Brain
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Accelerated aging
030227 psychiatry
3. Good health
Psychiatry and Mental health
Neuroprotective Agents
Multivariate Analysis
Lithium Compounds
Female
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 14401614 and 00048674
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Australian & New Zealand Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....7d692026cea20aef9a740fd131719186