Back to Search
Start Over
Porins from Salmonella typhimurium accelerate human blood coagulation in vitro by selective stimulation of thrombin activity: implications in septic shock DIC pathogenesis
- Source :
- Journal of endotoxin research 7 (2001): 211–217., info:cnr-pdr/source/autori:Di Micco B, Metafora S, Colonna G, Carteni M, Ragone R, Macalello MA, Di Micco P, Baroni A, Catalanotti P, Tufano MA./titolo:Porins from Salmonella typhimurium accelerate human blood coagulation in vitro by selective stimulation of thrombin activity: implications in septic shock DIC pathogenesis./doi:/rivista:Journal of endotoxin research/anno:2001/pagina_da:211/pagina_a:217/intervallo_pagine:211–217/volume:7
- Publication Year :
- 2001
-
Abstract
- The effect of porins, major hydrophobic outer membrane proteins purified from Salmonella typhimurium , on human blood coagulation was investigated. It was found that micromolar concentrations of porins accelerated markedly human blood coagulation in vitro. Using appropriate experiments, data were obtained showing that the main target of the porin-induced procoagulant effect was thrombin. A possible binding of porins with thrombin has been suggested to be the basis of this effect. The implications of this finding in the pathogenesis of the disseminated intravascular coagulation syndrome (DIC) occurring during the Gram-negative septic shock is discussed.
- Subjects :
- Salmonella typhimurium
Whole Blood Coagulation Time
Immunology
Antithrombin III
Thrombin
Porins
Cell Biology
Syndrome
030204 cardiovascular system & hematology
Disseminated Intravascular Coagulation
Microbiology
Shock, Septic
Antithrombins
03 medical and health sciences
0302 clinical medicine
Infectious Diseases
Prothrombin Time
bacteria
Humans
Partial Thromboplastin Time
Molecular Biology
Blood Coagulation
030215 immunology
Peptide Hydrolases
Subjects
Details
- ISSN :
- 09680519
- Volume :
- 7
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of endotoxin research
- Accession number :
- edsair.doi.dedup.....7d66f009debf673c267ebf632cb4e47a