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Coupling of Geant4-DNA physics models into the GATE Monte Carlo platform: Evaluation of radiation-induced damage for clinical and preclinical radiation therapy beams
- Source :
- Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 353, pp.46-55. ⟨10.1016/j.nimb.2015.04.024⟩, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Elsevier, 2015, 353, pp.46-55. ⟨10.1016/j.nimb.2015.04.024⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; The GATE Monte Carlo simulation platform based on the Geant4 toolkit is in constant improvement for dosimetric calculations. In this paper, we present the integration of Geant4-DNA processes into the GATE 7.0 platform in the objective to perform multi-scale simulations (from macroscopic to nanometer scale). We simulated three types of clinical and preclinical beams: a 6 MeV electron clinical beam, a X-ray irradiator beam and a clinical proton beam for which we validated depth dose distributions against measurements in water. Frequencies of energy depositions and DNA damage were evaluated using a specific algorithm in charge of allocating energy depositions to atoms constituting DNA molecules represented by their PDB (Protein Data Bank) description.
- Subjects :
- Coupling
Physics
Nuclear and High Energy Physics
Proton
Geant4-DNA
medicine.medical_treatment
Monte Carlo method
Physics::Medical Physics
GATE
Nanotechnology
computer.file_format
Electron
Protein Data Bank
[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Computational physics
Radiation therapy
medicine
Physics::Accelerator Physics
Nanodosimetry
Instrumentation
computer
Monte Carlo
Beam (structure)
Energy (signal processing)
Subjects
Details
- Language :
- English
- ISSN :
- 0168583X
- Database :
- OpenAIRE
- Journal :
- Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 353, pp.46-55. ⟨10.1016/j.nimb.2015.04.024⟩, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Elsevier, 2015, 353, pp.46-55. ⟨10.1016/j.nimb.2015.04.024⟩
- Accession number :
- edsair.doi.dedup.....7d5b03028c4f3827b4216540853c59cf
- Full Text :
- https://doi.org/10.1016/j.nimb.2015.04.024⟩