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Reproductive and hormonal factors and the risk of nonsmall cell lung cancer
- Source :
- International Journal of Cancer. 128:1404-1413
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Although exposure to estrogen may directly influence or modify the association between cigarette smoking and lung cancer risk, results from epidemiologic studies examining the association between reproductive and hormonal factors and risk of lung cancer among women have been inconsistent. Between 1998 and 2008, 430 women diagnosed with nonsmall cell lung cancer, 316 hospital controls and 295 population controls were recruited into the multi-center Maryland Lung Cancer Study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) according to reproductive and hormonal exposures adjusting for age, smoking, passive smoking, education and household income. Results were similar for hospital and population based controls, so the control groups were combined. Reduced risks of lung cancer were observed among women with greater parity (≥ 5 vs. 1-2 births: OR = 0.50, 95% CI = 0.32, 0.78, p-trend = 0.002) and later ages at last birth (≥ 30 vs.
- Subjects :
- Cancer Research
medicine.medical_specialty
Lung Neoplasms
Passive smoking
Hormone Replacement Therapy
medicine.medical_treatment
Population
Adenocarcinoma
medicine.disease_cause
Article
Risk Factors
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Risk factor
education
Lung cancer
Reproductive History
Aged
Gynecology
education.field_of_study
Obstetrics
business.industry
Smoking
Case-control study
Cancer
Hormone replacement therapy (menopause)
Odds ratio
Middle Aged
Prognosis
medicine.disease
Parity
Oncology
Case-Control Studies
Female
business
Contraceptives, Oral
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....7d4d28604028e19d5fe30b1a026ce15b