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A Nanomechanical Study on Deciphering the Stickiness of SARS-CoV-2 on Inanimate Surfaces
- Source :
- ACS Applied Materials & Interfaces
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- The SARS-CoV-2 virus that causes the COVID-19 epidemic can be transmitted via respiratory droplet-contaminated surfaces or fomites, which urgently requires a fundamental understanding of intermolecular interactions of the coronavirus with various surfaces. The corona-like component of the outer surface of the SARS-CoV-2 virion, named spike protein, is a key target for the adsorption and persistence of SARS-CoV-2 on various surfaces. However, a lack of knowledge in intermolecular interactions between spike protein and different substrate surfaces has resulted in ineffective preventive measures and inaccurate information. Herein, we quantified the surface interaction and adhesion energy of SARS-CoV-2 spike protein with a series of inanimate surfaces via atomic force microscopy under a simulated respiratory droplet environment. Among four target surfaces, polystyrene was found to exhibit the strongest adhesion, followed by stainless steel (SS), gold, and glass. The environmental factors (e.g., pH and temperature) played a role in mediating the spike protein binding. According to systematic quantification on a series of inanimate surfaces, the adhesion energy of spike protein was found to be (i) 0–1 mJ/m2 for hydrophilic inorganics (e.g., silica and glass) due to the lack of hydrogen bonding, (ii) 2–9 mJ/m2 for metals (e.g., alumina, SS, and copper) due to the variation of their binding capacity, and (iii) 6–11 mJ/m2 for hydrophobic polymers (e.g., medical masks, safety glass, and nitrile gloves) due to stronger hydrophobic interactions. The quantitative analysis of the nanomechanics of spike proteins will enable a protein–surface model database for SARS-CoV-2 to help generate effective preventive strategies to tackle the epidemic.
- Subjects :
- Materials science
Surface Properties
02 engineering and technology
Microscopy, Atomic Force
spike protein
010402 general chemistry
01 natural sciences
Hydrophobic effect
chemistry.chemical_compound
surface adhesion
Adsorption
General Materials Science
surface forces
chemistry.chemical_classification
SARS-CoV-2
Intermolecular force
Surface force
Temperature
COVID-19
Polymer
Adhesion
Hydrogen-Ion Concentration
intermolecular interaction
Stainless Steel
021001 nanoscience & nanotechnology
0104 chemical sciences
3. Good health
chemistry
Fomites
Spike Glycoprotein, Coronavirus
Biophysics
Polystyrenes
Glass
Gold
Polystyrene
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Nanomechanics
Research Article
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....7d49d0eed29699f3589d8ed9a591a51b