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Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments
- Source :
- Brazilian Journal of Psychiatry, Brazilian Journal of Psychiatry, Issue: ahead, Published: 12 JUN 2020, Brazilian Journal of Psychiatry v.43 n.2 2021, Brazilian Journal of Psychiatry (São Paulo. 1999. Online), Associação Brasileira de Psiquiatria (ABP), instacron:ABP, Brazilian Journal of Psychiatry, Vol 43, Iss 2, Pp 131-137 (2020), Brazilian Journal of Psychiatry, Volume: 43, Issue: 2, Pages: 131-137, Published: 12 JUN 2020
- Publication Year :
- 2020
-
Abstract
- Objectives: A previous study has shown that schizophrenia (SCZ) is accompanied by lowered levels of trace/metal elements, including cesium. However, it is not clear whether changes in cesium, rubidium, and rhenium are associated with activated immune-inflammatory pathways, cognitive impairments, and the symptomatology of SCZ. Methods: This study measured cesium, rubidium, and rhenium, cognitive impairments (using the Brief Assessment of Cognition in Schizophrenia [BACS]), and the levels of cytokines/chemokines interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and eotaxin (CCL11) in 120 patients with SCZ and 54 healthy controls. Severity of illness was assessed using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS), the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) Scale, and the Hamilton Depression Rating Scale (HAM-D). Results: Serum cesium was significantly lower in patients with SCZ as compared with controls. Further, serum cesium was significantly and inversely associated with CCL11 and TNF-α, but not IL-1β, in patients with SCZ; significant inverse associations were also noted between serum cesium levels and BPRS, FF, HAM-D, and SANS scores. Finally, cesium was positively correlated with neurocognitive probe results including the Tower of London, Symbol Coding, Controlled Word Association, Category Instances, Digit Sequencing Task, and List Learning tests. Conclusion: The results suggest that lowered serum cesium levels may play a role in the pathophysiology of SCZ, contributing to specific symptom domains including negative, depressive and fatigue symptoms, neurocognitive impairments (spatial working, episodic, and semantic memory and executive functions), and neuroimmune pathways.
- Subjects :
- Oncology
medicine.medical_specialty
neuroimmunomodulation
RC435-571
Cesium
chronic fatigue syndrome
03 medical and health sciences
0302 clinical medicine
Internal medicine
Fibromyalgia
Severity of illness
Brief Psychiatric Rating Scale
London
medicine
Chronic fatigue syndrome
Humans
Cognitive Dysfunction
Scale for the Assessment of Negative Symptoms
psychiatry_mental_health_studies
Psychiatry
Inflammation
business.industry
biomarkers
medicine.disease
Executive functions
030227 psychiatry
myalgic encephalomyelitis
Psychiatry and Mental health
Schizophrenia
Schizophrenic Psychology
Original Article
business
major depression
Neurocognitive
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1809452X
- Volume :
- 43
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
- Accession number :
- edsair.doi.dedup.....7d2d8ee529b7b53aee69197c7e74f047