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Risk of myocardial infarction among patients with gout: a nationwide population-based study
- Source :
- Rheumatology. 52:111-117
- Publication Year :
- 2012
- Publisher :
- Oxford University Press (OUP), 2012.
-
Abstract
- To investigate the association between gout and myocardial infarction (MI) in a representative cohort in Taiwan.Data were collected from the Taiwan National Health Insurance database. Adults20 years of age without history of MI were included. Patients were considered to have gout if they received a diagnosis of gout requiring medical treatment. Multivariate Cox proportional hazards models were used to evaluate the risk of MI in gout patients.Of the 704 503 patients included, 26 556 (3.8%) had gout. In total, 3718 (with gout, n = 463; without gout, n = 3255) patients had an MI, 299 (with gout, n = 35; without gout, n = 264) of whom died. The incidence of MI was 2.20 and 0.60 per 1000 patient-years in individuals with and without gout, respectively (log-rank test, P 0.001). After adjustment for age, sex and history of diabetes mellitus, hypertension, coronary heart disease (CHD), stroke and end-stage renal disease, gout was associated with MIs [hazard ratio (HR), 1.23] and non-fatal MIs (HR, 1.26). In individuals without cardiovascular risk factors, gout was associated with MIs (HR 1.84; 95% CI 1.51, 2.24) and non-fatal MIs (HR 1.80; 95% CI 1.49, 3.95), after adjustment for age and sex. Moreover, in our study population, the HRs for MI decreased as age increased.Gout is an independent risk factor for MI, and the increased risk of MI is present even in young people and those without cardiovascular risk factors.
- Subjects :
- Adult
Male
Risk
musculoskeletal diseases
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Gout
Myocardial Infarction
Taiwan
Risk Assessment
Rheumatology
Internal medicine
medicine
Humans
Pharmacology (medical)
Myocardial infarction
Stroke
Aged
Proportional Hazards Models
Aged, 80 and over
Proportional hazards model
business.industry
Incidence
Incidence (epidemiology)
Hazard ratio
nutritional and metabolic diseases
Middle Aged
medicine.disease
Surgery
Cardiovascular Diseases
Cohort
Population study
Female
business
Subjects
Details
- ISSN :
- 14620332 and 14620324
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Rheumatology
- Accession number :
- edsair.doi.dedup.....7d17491dcd877261efa7de73ae5940e3