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Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial
- Source :
- Annals of the American Thoracic Society, Annals of the American Thoracic Society, 17(7), 829-838
- Publication Year :
- 2020
-
Abstract
- Rationale: Bronchoscopic lung volume reduction with Zephyr Valves improves lung function, exercise tolerance, and quality of life of patients with hyperinflated emphysema and little to no collateral ventilation. Objectives: Post hoc analysis of patient-reported outcomes (PROs), including multidimensional measures of dyspnea, activity, and quality of life, in the LIBERATE (Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema) study are reported. Methods: A total of 190 patients with severe heterogeneous emphysema and little to no collateral ventilation in the target lobe were randomized 2:1 to the Zephyr Valve or standard of care. Changes in PROs at 12 months in the two groups were compared: dyspnea with the Transitional Dyspnea Index (TDI), focal score; the Chronic Obstructive Pulmonary Disease Assessment Test (CAT; breathlessness on hill/stairs); Borg; the EXAcerbations of Chronic pulmonary disease Tool–PRO, dyspnea domain; activity with the TDI, magnitude of task/effort/functional impairment, CAT (limited activities), and the St. George’s Respiratory Questionnaire (SGRQ), activity domain; and psychosocial status with the SGRQ, impacts domain, and CAT (confidence and energy). Results: At 12 months, patients using the Zephyr Valve achieved statistically significant and clinically meaningful improvements in the SGRQ; CAT; and the TDI, focal score, compared with standard of care. Improvements in the SGRQ were driven by the impacts and activity domains (P
- Subjects :
- Male
Exacerbation
medicine.medical_treatment
EMPHYSEMA
Bronchoscopic lung volume reduction
law.invention
0302 clinical medicine
Randomized controlled trial
Quality of life
law
Forced Expiratory Volume
Surveys and Questionnaires
interventional bronchoscopy
Medicine
PREDICTS MORTALITY
030212 general & internal medicine
LUNG-VOLUME-REDUCTION
Pneumonectomy
Zephyr Valve
Lung function
Original Research
Rehabilitation
Exercise Tolerance
Patient-centered outcomes
Prostheses and Implants
respiratory system
Middle Aged
Treatment Outcome
Pulmonary Emphysema
patient-reported outcomes
Anesthesia
Female
Pulmonary and Respiratory Medicine
REHABILITATION
Adult
Bronchi
Severe copd
OBSTRUCTIVE PULMONARY-DISEASE
CAPACITY
chronic obstructive pulmonary disease
03 medical and health sciences
severe emphysema
SEVERE COPD
Bronchoscopy
PATIENT-CENTERED OUTCOMES
Humans
Aged
business.industry
respiratory tract diseases
PHYSICAL-ACTIVITY
030228 respiratory system
EXACERBATION
Quality of Life
business
Adult Pulmonary
Subjects
Details
- ISSN :
- 23256621
- Volume :
- 17
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Annals of the American Thoracic Society
- Accession number :
- edsair.doi.dedup.....7d1637fa3191839d90384734cfdc8794