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Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
- Source :
- Diagnostics, Diagnostics, Vol 11, Iss 403, p 403 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The C-reactive protein-to-albumin ratio is a proven prognostic predictor of nasopharyngeal carcinoma. However, the role of the C-reactive protein-to-albumin ratio in other head and neck cancers remains unclear. This meta-analysis explored the prognostic value of the C-reactive protein-to-albumin ratio in head and neck cancers. A systematic search was conducted. Outcomes of interest included overall survival, disease-free survival, and distant metastasis–free survival. The hazard ratio with 95% confidence interval was pooled using a random-effects model. A total of 11 publications from the literature were included, allowing for the analysis of 7080 participants. Data pooling demonstrated that pretreatment C-reactive protein-to-albumin ratio had a hazard ratio of 1.88 (95% CI: 1.49−2.37, p < 0.001) for predicting overall survival, 1.91 (95% CI: 1.18−3.08, p = 0.002) for disease-free survival, and 1.46 (95% CI: 1.08−1.96, p = 0.001) for distant metastasis–free survival. Subgroup analysis showed that the C-reactive protein-to-albumin ratio is a significant prognostic marker for various head and neck cancers. An elevated pretreatment C-reactive protein-to-albumin ratio predicts a worse prognosis for patients with head and neck cancers. Therefore, the C-reactive protein-to-albumin ratio could serve as a potential prognostic biomarker facilitating treatment stratification.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
disease-free survival
overall survival
Clinical Biochemistry
Subgroup analysis
Review
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
distant metastasis–free survival
lcsh:R5-920
biology
business.industry
Head and neck cancer
C-reactive protein
Hazard ratio
Albumin
medicine.disease
Confidence interval
meta-analysis
030104 developmental biology
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
Meta-analysis
biology.protein
head and neck cancer
C-reactive protein-to-albumin ratio
lcsh:Medicine (General)
business
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....7d09b530b8678cbc445d331339fd97d8