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Biomarkers of drug resistance in ovarian cancer - an update
- Source :
- Expert review of molecular diagnostics. 19(6)
- Publication Year :
- 2019
-
Abstract
- Introduction: Ovarian cancer, consisting predominantly of ovarian carcinoma, is the most lethal gynecologic malignancy. Diagnosis at the advanced stage, particularly in high-grade serous carcinoma which is the most common and clinically aggressive histotype, is a major factor negatively affecting survival, while tumor heterogeneity and chemoresistance often preclude complete elimination of tumor cells even following radical surgery and combination chemotherapy. Recently, inhibition of angiogenesis and inhibition of poly (ADP-ribose) polymerase (PARP) have shown benefit in the treatment of this cancer. Areas covered: Extensive research has identified molecules associated with resistance to chemotherapy and implicated several biomarkers affecting response to antiangiogenic therapy and PARP inhibition. This review discusses recent data in this field. The presented data, gathered in a PubMed search focusing on the years 2016-2018, focus on regulators of the cell cycle and mitosis, cancer stem cell-related molecules, the immune response, receptor tyrosine kinases and related signaling pathways, BRCA and other DNA repair molecules, microRNAs, and other cancer-associated molecules. Expert opinion: Future research is likely to focus on histotype-specific analyses of clinical specimens and patient-generated cultures applying cutting-edge molecular technology, in the aim of identifying major regulators of chemotherapy response.
- Subjects :
- 0301 basic medicine
Serous carcinoma
Angiogenesis
Mitosis
Antineoplastic Agents
Receptor tyrosine kinase
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Ovarian carcinoma
Genetics
Biomarkers, Tumor
Medicine
Humans
Molecular Biology
Expert Testimony
BRCA2 Protein
Ovarian Neoplasms
biology
business.industry
BRCA1 Protein
Cell Cycle
Immunity
Cancer
Combination chemotherapy
Cell cycle
medicine.disease
MicroRNAs
030104 developmental biology
Drug Resistance, Neoplasm
030220 oncology & carcinogenesis
biology.protein
Cancer research
Neoplastic Stem Cells
Molecular Medicine
Female
Disease Susceptibility
business
Ovarian cancer
Signal Transduction
Subjects
Details
- ISSN :
- 17448352
- Volume :
- 19
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Expert review of molecular diagnostics
- Accession number :
- edsair.doi.dedup.....7cffd6b7e9771b5700a457b28d35ae9c