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Relevant Physicochemical Methods to Functionalize, Purify, and Characterize Surface-Decorated Lipid-Based Nanocarriers
- Source :
- Molecular Pharmaceutics, Molecular Pharmaceutics, American Chemical Society, 2021, 18 (1), pp.44-64. ⟨10.1021/acs.molpharmaceut.0c00857⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Surface functionalization of lipid-based nanocarriers (LBNCs) with targeting ligands has attracted huge interest in the field of nanomedicines for their ability to overcome some physiological barriers and their potential to deliver an active molecule to a specific target without causing damage to healthy tissues. The principal objective of this review is to summarize the present knowledge on LBNC decoration used for biomedical applications, with an emphasis on the ligands used, the functionalization approaches, and the purification methods after ligand corona formation. The most potent experimental techniques for the LBNC surface characterization are described. The potential of promising methods such as nuclear magnetic resonance spectroscopy and isothermal titration calorimetry to characterize ligand surface corona is also outlined.
- Subjects :
- Pharmaceutical Science
Nanotechnology
02 engineering and technology
010402 general chemistry
01 natural sciences
Drug Delivery Systems
Drug Discovery
Animals
Humans
Purification methods
ComputingMilieux_MISCELLANEOUS
Targeting ligands
Drug Carriers
Ligand
Chemistry
Isothermal titration calorimetry
021001 nanoscience & nanotechnology
Lipids
0104 chemical sciences
Nanomedicine
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
Nanoparticles
Molecular Medicine
Surface modification
Nanocarriers
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 15438384 and 15438392
- Database :
- OpenAIRE
- Journal :
- Molecular Pharmaceutics, Molecular Pharmaceutics, American Chemical Society, 2021, 18 (1), pp.44-64. ⟨10.1021/acs.molpharmaceut.0c00857⟩
- Accession number :
- edsair.doi.dedup.....7cf7989c9cb7a722c058e964f7cf9da5