Back to Search
Start Over
Role of the DNA Damage Response in Human Papillomavirus RNA Splicing and Polyadenylation
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 19, Iss 6, p 1735 (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is activated. Recent research has shown that the DDR factors also interact with RNA binding proteins and affects RNA processing. DDR factors activated by DNA damage and that associate with HPV DNA can recruit splicing factors and RNA binding proteins to the HPV DNA and induce HPV late gene expression. This induction is the result of altered alternative polyadenylation and splicing of HPV messenger RNA (mRNA). HPV uses the DDR machinery to replicate its DNA genome and to activate HPV late gene expression at the level of RNA processing.
- Subjects :
- Gene Expression Regulation, Viral
0301 basic medicine
Polyadenylation
DNA repair
DNA damage
RNA Splicing
RNA-binding protein
Review
Biology
papillomavirus
DDR
Catalysis
lcsh:Chemistry
Inorganic Chemistry
splicing
03 medical and health sciences
TRAP150
0302 clinical medicine
SR protein
Humans
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Papillomaviridae
Molecular Biology
Spectroscopy
Polymerase
BCLAF1
Messenger RNA
Organic Chemistry
U2AF65
virus diseases
General Medicine
BRCA1
female genital diseases and pregnancy complications
Computer Science Applications
Cell biology
body regions
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
RNA splicing
biology.protein
SR proteins
DNA Damage
hnRNP C
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....7cf6acce5aa1e91219d24e64c711fa68