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Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 21, Iss 5579, p 5579 (2020), Volume 21, Issue 15
- Publication Year :
- 2020
-
Abstract
- Senescence-accelerated mouse prone 10 (SAMP10) exhibits cerebral atrophy and depression-like behavior. A line of SAMP10 with spontaneous mutation in the Slc5a2 gene encoding the sodium-glucose cotransporter (SGLT) 2 was named SAMP10/TaSlc-Slc5a2slc (SAMP10-&Delta<br />Sglt2) and was identified as a renal diabetes model. In contrast, a line of SAMP10 with no mutation in SGLT2 (SAMP10/TaIdrSlc, SAMP10(+)) was recently established under a specific pathogen-free condition. Here, we examined the mutation effect in SGLT2 on brain function and longevity. No differences were found in the survival curve, depression-like behavior, and age-related brain atrophy between SAMP10-&Delta<br />Sglt2 and SAMP10(+). However, memory retention was lower in SAMP10-&Delta<br />Sglt2 mice than SAMP10(+). Amyloid beta (A4) precursor-like protein 1 (Aplp1) expression was significantly lower in the hippocampus of SAMP10-&Delta<br />SGLT2 than in SAMP10(+) at 2 months of age, but was similar at 12 months of age. CaM kinase-like vesicle association (Camkv) expression was remarkably lower in SAMP10(+). These genes have been reported to be involved in dendrite function. Amyloid precursor proteins have been reported to involve in maintaining homeostasis of glucose and insulin. These results suggest that mutation in SGLT2 results in down-regulation of Aplp1 in young age, which can lead to poor memory retention in old age.
- Subjects :
- 0301 basic medicine
Aging
medicine.medical_treatment
lcsh:Chemistry
Amyloid beta-Protein Precursor
Mice
0302 clinical medicine
glucosuria
lcsh:QH301-705.5
Spectroscopy
Cellular Senescence
Age Factors
Brain
Neurodegenerative Diseases
General Medicine
amyloid beta (A4) precursor-like protein 1
Computer Science Applications
Sodium/Glucose Cotransporter 2
medicine.medical_specialty
Amyloid
Amyloid beta
Biology
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Atrophy
Sodium-Glucose Transporter 2
Memory
Internal medicine
medicine
Animals
Humans
APLP1
Physical and Theoretical Chemistry
Molecular Biology
senescence-accelerated mouse prone 10
Cerebral atrophy
Memory Disorders
Insulin
Organic Chemistry
sodium-glucose cotransporter 2
medicine.disease
Synapsins
memory retention
030104 developmental biology
Endocrinology
Glucose
lcsh:Biology (General)
lcsh:QD1-999
Gene Expression Regulation
Mutation
biology.protein
030217 neurology & neurosurgery
Homeostasis
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....7cefea4b6bf81243bf5886bf642a5ee1