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Absence or decreased endogenous thiosulfaturia: a cause of recurrent calcium nephrolithiasis
- Source :
- International urology and nephrology. 36(4)
- Publication Year :
- 2005
-
Abstract
- In two earlier publications we reported excellent therapeutic results in patients with recurrent calcium nephrolithiasis, using oral or intravenous i.v. sodium thiosulfate on the one hand, and on treatment of tumorus-soft periarticular tissues calcifications on the other. Thus, we considered useful to measure endogenous thiosulfaturia, using a specific HPLC method, in 25 healthy adult males and 25 patients with recurrent calcium nephrolithiasis. Healthy adult males excreted between 11 and 16 μ M/24 hour of endogenous thiosulfate, while patients with recurrent calcium nephrolithiasis excreted significantly lower amounts of 6 and 10 μ M/24 hour, except one patient, who did not excrete endogenous thiosulfate, reflecting probably a genetic abnormality. Thiosulfate is a unique agent for treatment of recurrent calcium nephrolithiasis as well as some other abnormal calcium depositions. Two doses of 5 mM sodium thiosulfate daily are therapeutically sufficient. © 2004 Kluwer Academic Publishers.
- Subjects :
- Nephrology
Adult
Male
medicine.medical_specialty
Urology
Thiosulfates
Abnormal calcium
Endogeny
Sodium thiosulfate
chemistry.chemical_compound
Kidney Calculi
Recurrence
Internal medicine
medicine
Humans
In patient
Hplc method
Thiosulfate
Calcium nephrolithiasis
business.industry
Middle Aged
Endocrinology
chemistry
Calcium
business
Subjects
Details
- ISSN :
- 03011623
- Volume :
- 36
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International urology and nephrology
- Accession number :
- edsair.doi.dedup.....7ce9a01475466ef07666487a6bfd8675