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Non-coding RNAs: Regulators of glioma cell epithelial-mesenchymal transformation
Non-coding RNAs: Regulators of glioma cell epithelial-mesenchymal transformation
- Source :
- Pathology, research and practice. 215(9)
- Publication Year :
- 2019
-
Abstract
- GBM (glioblastoma multiforme) is the most malignant form of glioma and is the most commonly occurring primary malignant brain tumour. GBM is difficult to completely excise, resulting in an extremely high recurrence rate. The occurrence of an aggressive glioma phenotype depends on EMT (epithelial-mesenchymal transformation), in which epithelial cells transform into mesenchymal cells by losing their cell-cell adhesion and polarity. NcRNAs (non-coding RNAs) play a significant role in the cellular progression from a normal phenotype to a cancerous phenotype. Recently, many studies have shown that there are two essential regulatory ncRNAs, miRNAs (microRNAs) and lncRNAs, which are closely related to EMT. In this review, we conducted a comprehensive investigation of the dysregulated lncRNAs and miRNAs in gliomas with particular attention to the function and regulatory mechanisms of several important lncRNAs and miRNAs, and we discussed their roles as glioma diagnostic and prognostic biomarkers and their potential clinical applications as therapeutic targets.
- Subjects :
- 0301 basic medicine
Epithelial-Mesenchymal Transition
Glioma cell
Biology
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Glioma
microRNA
medicine
Biomarkers, Tumor
Humans
Brain Neoplasms
Mesenchymal stem cell
Cell Biology
medicine.disease
Phenotype
Gene Expression Regulation, Neoplastic
Transformation (genetics)
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Biomarker (medicine)
RNA, Long Noncoding
Function (biology)
Subjects
Details
- ISSN :
- 16180631
- Volume :
- 215
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Pathology, research and practice
- Accession number :
- edsair.doi.dedup.....7ce1eb3857347ee9e3c9d11c52d14d43