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Relatedness and heterogeneity at the near-terminal end of the genome of a parapoxvirus bovis 1 strain (B177) compared with parapoxvirus ovis (Orf virus)
- Source :
- The Journal of general virology. 84(Pt 5)
- Publication Year :
- 2003
-
Abstract
- The present study provides for the first time an extended investigation of individual genes located at the near-terminal right end of the genome of parapoxvirus bovis 1, Bovine papular stomatitis virus (BPSV) strain B177 and Orf virus (ORFV). Comparison of the respective DNA sequences of ORFV strain D1701 (9.9 kbp) and BPSV B177 (7.7 kbp) revealed a very similar organization of closely related genes transcribed in a rightward orientation. The most salient findings of this study were: (i) the absence of the ORFV-specific vascular endothelial growth factor (VEGF-E) gene in the BPSV isolate; (ii) the presence of an interleukin-10 (IL-10) orthologue; and (iii) the detection of three new genes encoding ankyrin-repeat-containing polypeptides. These results not only contribute to potential improvements of future molecular differentiation between the parapoxvirus species, but also shed new light on different pathobiologies among parapoxviruses.
- Subjects :
- Molecular Sequence Data
Genome, Viral
Genome
DNA sequencing
Virus
Viral Proteins
Bovine papular stomatitis
Virology
medicine
Animals
Amino Acid Sequence
Gene
Ovis
Genetics
Parapoxvirus
Strain (chemistry)
biology
Genetic Variation
Orf virus
Sequence Analysis, DNA
biology.organism_classification
medicine.disease
Interleukin-10
Cattle
Subjects
Details
- ISSN :
- 00221317
- Volume :
- 84
- Issue :
- Pt 5
- Database :
- OpenAIRE
- Journal :
- The Journal of general virology
- Accession number :
- edsair.doi.dedup.....7cdf21c81c7a6d33b8449adff384df56