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Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis
- Source :
- Communications Biology, Communications Biology, 2022, 5 (1), pp.113. ⟨10.1038/s42003-022-03053-0⟩, Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- Somitogenesis, the segmentation of the antero-posterior axis in vertebrates, is thought to result from the interactions between a genetic oscillator and a posterior-moving determination wavefront. The segment (somite) size is set by the product of the oscillator period and the velocity of the determination wavefront. Surprisingly, while the segmentation period can vary by a factor three between 20 °C and 32 °C, the somite size is constant. How this temperature independence is achieved is a mystery that we address in this study. Using RT-qPCR we show that the endogenous fgf8 mRNA concentration decreases during somitogenesis and correlates with the exponent of the shrinking pre-somitic mesoderm (PSM) size. As the temperature decreases, the dynamics of fgf8 and many other gene transcripts, as well as the segmentation frequency and the PSM shortening and tail growth rates slows down as T–Tc (with Tc = 14.4 °C). This behavior characteristic of a system near a critical point may account for the temperature independence of somitogenesis in zebrafish.
- Subjects :
- MESH: Fibroblast Growth Factor 8 / metabolism
animal structures
Embryo, Nonmammalian
Fibroblast Growth Factor 8
QH301-705.5
MESH: p-Aminoazobenzene / pharmacology
[SDV]Life Sciences [q-bio]
Embryonic Development
Medicine (miscellaneous)
MESH: Embryonic Development / physiology
MESH: Embryonic Development / genetics
General Biochemistry, Genetics and Molecular Biology
[PHYS] Physics [physics]
MESH: Embryo, Nonmammalian / metabolism
MESH: Fibroblast Growth Factor 8 / genetics
MESH: Gene Expression Regulation, Developmental / physiology
Animals
MESH: Animals
RNA, Messenger
Biology (General)
MESH: p-Aminoazobenzene / analogs & derivatives
MESH: Zebrafish
Zebrafish
[PHYS]Physics [physics]
Body patterning
MESH: RNA, Messenger / metabolism
Gene Expression Regulation, Developmental
[SDV] Life Sciences [q-bio]
stomatognathic diseases
Embryonic induction
p-Aminoazobenzene
embryonic structures
MESH: RNA, Messenger / genetics
General Agricultural and Biological Sciences
Subjects
Details
- ISSN :
- 23993642
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Communications Biology
- Accession number :
- edsair.doi.dedup.....7cdacdfae2027ebc39a515e0e9270e64