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The Use of Tethered Bilayer Lipid Membranes to Identify the Mechanisms of Antimicrobial Peptide Interactions with Lipid Bilayers
- Source :
- Antibiotics, Antibiotics, Vol 8, Iss 1, p 12 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This review identifies the ways in which tethered bilayer lipid membranes (tBLMs) can be used for the identification of the actions of antimicrobials against lipid bilayers. Much of the new research in this area has originated, or included researchers from, the southern hemisphere, Australia and New Zealand in particular. More and more, tBLMs are replacing liposome release assays, black lipid membranes and patch-clamp electrophysiological techniques because they use fewer reagents, are able to obtain results far more quickly and can provide a uniformity of responses with fewer artefacts. In this work, we describe how tBLM technology can and has been used to identify the actions of numerous antimicrobial agents.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Antimicrobial peptides
Peptide
02 engineering and technology
Review
Biochemistry
Microbiology
03 medical and health sciences
antimicrobial peptides
Bilayer lipid membranes
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Lipid bilayer
Electrical impedance spectroscopy
chemistry.chemical_classification
Liposome
Chemistry
lcsh:RM1-950
tethered bilayer lipid membranes
food and beverages
021001 nanoscience & nanotechnology
Antimicrobial
electrical impedance spectroscopy
lcsh:Therapeutics. Pharmacology
030104 developmental biology
Infectious Diseases
Membrane
Biophysics
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 20796382
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Antibiotics
- Accession number :
- edsair.doi.dedup.....7cd4f956935750617ac5eb675ee70224