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Treatment of primary FSGS in adults
- Source :
- Journal of the American Society of Nephrology : JASN. 23(11)
- Publication Year :
- 2012
-
Abstract
- Over the last 20 years, primary FSGS has emerged as one of the leading causes of idiopathic nephrotic syndrome in adults, particularly among African Americans. In nephrotic patients, progression to ESRD often occurs over the course of 5-10 years, whereas non-nephrotic patients and those entering a remission have an extremely favorable prognosis. As a result, it is in patients who remain persistently nephrotic despite conservative therapy that a more aggressive therapeutic approach is taken. Primary FSGS was once considered an entity nonresponsive to prednisone or immunosuppressive agents, but it has become apparent over the last 20 years that a substantial portion of nephrotic adults with primary FSGS do respond to treatment with a significantly improved prognosis. The recent histologic classification proposed for FSGS has provided additional insights into the prognosis and response to therapy. This article reviews the current knowledge regarding the presentation, prognosis, and therapeutic approach in adults with primary FSGS.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Pediatrics
Response to therapy
business.industry
Glomerulosclerosis, Focal Segmental
Drug Resistance
General Medicine
Favorable prognosis
urologic and male genital diseases
Idiopathic Nephrotic Syndrome
Prognosis
female genital diseases and pregnancy complications
Primary FSGS
Therapeutic approach
Nephrology
Prednisone
medicine
Humans
In patient
Steroids
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 15333450
- Volume :
- 23
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Accession number :
- edsair.doi.dedup.....7ccee986bbefbf5e55ea7d4ee3a00d08