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S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways
- Source :
- Biochemical and Biophysical Research Communications. 491:821-826
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Gastric cancer remains as a common lethal malignancy worldwide. Developing novel anti-gastric cancer drugs with minimal side effects is necessary to address this public health issue. S-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against tumors. In this study, we examined the effect of SAMC on human gastric carcinoma growth in vivo and explored the underlying mechanism. Human gastric cancer SGC-7901 cells were inoculated subcutaneously in BALB/c nude mice. When xenograft tumors reached about 100 mm3, mice were treated with SAMC for 30 days. We observed that SAMC administration in mice effectively delayed the growth of SGC-7901 xenografts without signs of toxicity. TUNEL staining confirmed that the tumors from SAMC-treated mice exhibited a markedly higher apoptotic index. Mechanistic studies suggested that this activity may arise from its effects on the caspase activation and modulation of MAPK and PI3K/Akt signaling pathways. Taken together, these data support development of SAMC as a potential agent for gastric cancer therapy.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
MAP Kinase Signaling System
Biophysics
Mice, Nude
Antineoplastic Agents
Apoptosis
Biochemistry
Mice
Phosphatidylinositol 3-Kinases
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
Cell Line, Tumor
Animals
Humans
Medicine
Cysteine
Molecular Biology
Protein kinase B
PI3K/AKT/mTOR pathway
Mice, Inbred BALB C
TUNEL assay
Dose-Response Relationship, Drug
business.industry
Cancer
Cell Biology
medicine.disease
Treatment Outcome
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
Toxicity
Cancer research
Female
Signal transduction
business
Proto-Oncogene Proteins c-akt
Signal Transduction
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 491
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....7cbac15b71e88ce045dc4ee9d31d3b92