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Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents
- Source :
- Chemical communications (Cambridge, England). 56(65)
- Publication Year :
- 2020
-
Abstract
- Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.
- Subjects :
- Cell Survival
Pyridines
chemistry.chemical_element
Antineoplastic Agents
010402 general chemistry
Ligands
01 natural sciences
Catalysis
Ruthenium
HeLa
Surface-Active Agents
Coordination Complexes
Amphiphile
Cervical carcinoma
Materials Chemistry
Humans
biology
010405 organic chemistry
Light activated
Optical Imaging
Metals and Alloys
Water
General Chemistry
biology.organism_classification
Combinatorial chemistry
0104 chemical sciences
3. Good health
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Water soluble
chemistry
Solubility
Ceramics and Composites
Phototoxicity
Reactive Oxygen Species
HeLa Cells
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 56
- Issue :
- 65
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....7cab5041b057dddc9f04d1a9368ace63