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Biochemical properties and function of poly(ADP-ribose) glycohydrolase
- Source :
- Biochimie. 77:433-438
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- We describe here the latest observations on poly(ADP-ribose) glycohydrolase. There is now extensive evidence that this nuclear enzyme is an endo-exoglycosidase which has a key role to perform in the removal of polymers which interact with proteins through covalent and non-covalent interactions. Also, we have developed a zymogram which will permit the isolation of the various isoforms of the glycohydrolase and the eventual cloning of this enzyme. Finally, we have evidence that very short oligomers and even monomers of ADP-ribose covalently bound to proteins can be removed by poly(ADP-ribose) glycohydrolase.
- Subjects :
- Cell Nucleus
chemistry.chemical_classification
PARG
DNA Repair
Glycoside Hydrolases
Poly ADP ribose polymerase
General Medicine
Biochemistry
Isoenzymes
Structure-Activity Relationship
chemistry.chemical_compound
Enzyme
Monomer
chemistry
Covalent bond
Animals
Humans
NAD+ kinase
Polyacrylamide gel electrophoresis
Poly(ADP-ribose) glycohydrolase
Subjects
Details
- ISSN :
- 03009084
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Biochimie
- Accession number :
- edsair.doi.dedup.....7ca90a1ca7a85f654ee2fa1fa18485bf