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Novel pharmacological therapies for the treatment of endometriosis
- Source :
- Expert review of clinical pharmacology. 15(9)
- Publication Year :
- 2022
-
Abstract
- Endometriosis is a chronic, estrogen-dependent, inflammatory disease associated with pelvic pain, infertility, impaired sexual function, and psychological suffering. Therefore, tailored patient management appears of primary importance to address specific issues and identify the appropriate treatment for each woman. Over the years, abundant research has been carried out with the objective to find new therapeutic approaches for this multifaceted disease.This narrative review aims to present the latest advances in the pharmacological management of endometriosis. In particular, the potential role of GnRH antagonists, selective progesterone receptor modulators (SPRMs), and selective estrogen receptors modulators (SERMs) will be discussed. We performed a literature search in PubMed and Embase, and selected the best quality evidence, giving preference to the most recent and definitive original articles and reviews.Medical therapy represents the cornerstone of endometriosis management, although few advances have been made in the last decade. Most studies have focused on the evaluation of the efficacy and safety of GnRH antagonists (plus add-back therapy in cases of prolonged treatment), which should be used as second-line treatment options in selected cases (i.e. non-responders to first-line treatments). Further studies are needed to identify the ideal treatment for women with endometriosis.
- Subjects :
- Selective Estrogen Receptor Modulators
linzagolix
relugolix
Endometriosis
Estrogens
General Medicine
elagolix
GnRH antagonist
SERM
SPRM
endometriosis
Gonadotropin-Releasing Hormone
Hormone Antagonists
Receptors, Estrogen
Humans
Settore MED/40 - Ginecologia e Ostetricia
Pharmacology (medical)
Female
General Pharmacology, Toxicology and Pharmaceutics
Receptors, Progesterone
Subjects
Details
- ISSN :
- 17512441
- Volume :
- 15
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Expert review of clinical pharmacology
- Accession number :
- edsair.doi.dedup.....7c9eba5b3b41b911efdc05ad1ba678ce